The role of fructosamine and hemoglobin levels in non-diabetic patients with thoracica cute aortic dissection

Objectives: Recent investigations demonstrated that oxidative stress a crucial role in the etiology of acute aortic dissection (AAD). The levels of fructosamine and glycosylated hemoglobin (HbA1c) have been considered as marker to reflect oxidative stress in various diseases. Therefore, this study was planned to investigate the levels of fructosamine and HbA1c in patients with thoracic ADD. Methods: The study sample included 235 consecutive patients for suspected thoracic ADD, a definitive and reliable diagnosis of thoracic ADD was established in 70 of 235 suspected thoracic ADD patients. Results: The levels of serum fructosamine, HbA1c and random blood glucose were significantly higher in thoracic ADD than in those without. There were no statistically differences between the two groups with respect to age and gender, random blood glucose, creatine kinase (CK), creatine kinase isoenzyme (CK-MB), total protein (TP), low density lipoprotein-cholesterol (LDL-C), triglyceride (TG) and total cholesterol (TC). The correlation analysis showed no correlation between random blood glucose and fructosamine, HbA1c in patients with thoracic AAD. Of note, increased fructosamine and HbA1c levels were associated with thoracic ADD in logistic regression analysis (OR=1.251, P<0.001, 95% CI: 1.060-1.480; OR=2.330, P=0.005, 95% CI: 1.420-3.281). The receiver operating characteristics (ROC) curve analysis of fructosamine and HbA1c exhibited some significant results in estimating thoracic ADD patients. Conclusions: Our data suggest that the increased levels of fructosamine and HbA1c are associated with thoracic ADD, and the results indicate that increased levels of fructosamine and HbA1c may be risk factor of thoracic ADD.